Recent publications (Corresponded):
Cell Systems 2025; Nature Reviews Bioengineering 2024; Nature Chemistry 2024; Cell Chemical Biology 2023;
Welcome to Yiwei Lab
We study the biophysics and mechanobiology of organoids and stem cells. We also developed powerful tools on both organ-level and single cell level to enrich our goal. We are situated in Wuhan optics valley, China, where we are proud to have created a creative, collaborative and open-minded Bioengineering Lab.
News & Updates
Check our new Nature Communications paper!
Our new Nature Communications paper introduced a mechanobiochemical circuits that divert WNT signaling in two different ways via phase separation of AXIN condensates. Such circuit guide mechanical augment of cell proliferation in healthy intestinal organoids but suppress cell growth in CRC organoids.
Check our new Nature Protocols paper!
Our new Nature Protocols paper introduced a detailed protocols for our new technology to high-throughput and proteome-widely discover endogenous phase separating proteins and biomolecular condensates. We help everyone are able to use our technology and welcome any queries.
Check our new Cell Systems Biology paper!
Our new Cell Systems paper developed a new tumor-adipose assembloid model, which reveals mechaical crostalk between cancer cells and adipocytes, as well as its consequence on cell fate change.